Increased glomerular albumin permeability in old spontaneously hypertensive rats
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چکیده
منابع مشابه
Glomerular atrial natriuretic factor receptors in spontaneously hypertensive rats.
There are differences in the renal handling of sodium between spontaneously hypertensive rats (SHR) and their normotensive controls. We investigated whether this difference may be associated with changes in plasma and tissue atrial natriuretic factor (ANF) levels and with alterations in glomerular ANF receptors at 4, 8, 12, and 16 weeks of age. Age-matched Wistar-Kyoto (WKY) and Wistar rats wer...
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Micropuncture and/or morphologic studies were performed in intact Wistar-Kyoto rats (WKY) (group 0), intact spontaneously hypertensive rats (SHR) (groups 1 and 5), uninephrectomized (UNX) WKY (groups 2 and 6), and UNX SHR (groups 3 and 4, 7 and 8). UNX was performed when rats were 5 wk of age. Groups 0-4 were observed for 34 wk after which whole kidney clearance and morphologic studies were per...
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Intraventricular administration of nicotine produced a biphasic effect, consisting of an initial rise than a slight fall in blood pressure in unanaesthetized rats. Spontaneously hypertensive rate (SHR) showed increased pressor responses, but these responses were within normal limits in renal hypertensive and DOCA-saline hypertensive rats. The blood pressure response to nicotine in SHR was aboli...
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The increased neural atrial natriuretic factor (ANF) concentrations in spontaneously hypertensive rats compared with Wistar-Kyoto control rats prompted us to examine the basis of this phenomenon. Central and peripheral neural tissues from both strains were processed under rigorous antiproteolytic conditions, which were monitored by degradation of purified and iodo-labeled proANF or synthetic AN...
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The spontaneous tone of vascular smooth muscle is augmented in hypertension. The present study examined the role of nitric oxide (NO), cyclooxygenase (COX), thromboxane A(2)/prostanoid (TP) and PGE(2)/prostanoid (EP-1) receptors, reactive oxygen species, and large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in the regulation of spontaneous tone in renal arteries of young and mature Wist...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2004
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfh276